| Title | Season | Episode # | First Aired |
|---|---|---|---|
| The Tooth Fairy's TATS 2000 | 4 | 49 | Wednesday April 5, 2000 |
| Cartman's Silly Hate Crime 2000 | 4 | 50 | Wednesday April 12, 2000 |
| Timmy! 2000 | 4 | 51 | Wednesday April 19, 2000 |
| Quintuplets 2000 | 4 | 52 | Wednesday April 26, 2000 |
| Cartman Joins NAMBLA | 4 | 53 | Wednesday June 21, 2000 |
| Cherokee Hair Tampons | 4 | 54 | Wednesday June 28, 2000 |
| Chef Goes Nanners | 4 | 55 | Wednesday July 5, 2000 |
| Something You Can Do With Your Finger | 4 | 56 | Wednesday July 12, 2000 |
| Do the Handicapped Go to Hell? (1) | 4 | 57 | Wednesday July 19, 2000 |
| Probably (2) | 4 | 58 | Wednesday July 26, 2000 |
| 4th Grade | 4 | 59 | Wednesday November 8, 2000 |
| Trapper Keeper | 4 | 60 | Wednesday November 15, 2000 |
| Helen Keller! The Musical | 4 | 61 | Wednesday November 22, 2000 |
| Pip (a.k.a. Great Expectations) | 4 | 62 | Wednesday November 29, 2000 |
| Fat Camp | 4 | 63 | Wednesday December 6, 2000 |
| The Wacky Molestation Adventure | 4 | 64 | Wednesday December 13, 2000 |
| A Very Crappy Christmas | 4 | 65 | Wednesday December 20, 2000 |